Skin Repair Properties of Aloe Vera in Albino Mice

The purpose of this study was to evaluate the effect of topical administration of Aloe vera on excision wound healing in mice. Mechanical skin lesion were used here to assess the efficacy of Aloe vera applied topically. Macroscopic and microscopic evaluation of skin lesions was performed. Excision wounds were made on the back of albino mice. Albino mice were divided into following groups, as control, and treatment. The control group did not receive any treatment. The wound tissues were removed on 6th and 12th day for histopathological analysis. Results showed that Aloe vera increased epithelialization and decreased inflammation but did not have any effect on percentage of wound contraction. The microscopic examination of the wound tissue collected and kept as control showed marked increase in collagen accumulation and fibroblast cell proliferation with the newly formed blood vessels. The fibroblast cell was still swollen, plumped and oval. Collagen fiber was also thin, fine and intermixes with the matrix. The wound healing property of Aloe vera gel has been attributed to Mannose-6-phosphate. Actually, glucomannan and plant growth hormone gibberellins interacts with growth factor receptors of fibrobroblast and stimulate its activity and proliferation for increases collagen synthesis in topical and oral administration of Aloe vera. The Aloe Vera administration influence collagen composition (more type III) and increased collagen cross linking for wound contraction and improving breaking strength. It also increases synthesis of hyaluronic acid and dermatan sulfate in the granulation tissue of a healing wound. It was concluded that Aloe vera can significantly stimulate epithelialization and reduce inflammation in full-thickness wounds in mice. These studies show that Aloe Vera demonstrate significant antiinflammatory effects in mice dermal inflammation and wound-healing.